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Taking care of women's reproductive health is the key to a healthy future
of not only every family, but the whole country
According to WHO estimates, the number of patients diagnosed with cancer of the reproductive system grows by about 1.27% annually. 1

If this trend continues, the increase may be more than 33% by 2050. However, this dynamics is driven not only by higher morbidity in general, but also by better diagnostics at early stages. The top ten of cancers affecting women in Russia and worldwide includes breast, uterine and ovarian cancers.2
Any measures aimed at early diagnosis and prevention of these conditions are at the heart of the cancer fighting strategy

Relevant issues to be addressed by our society:

This is critically important now, when cancers are getting younger and manifest at an earlier age
+80% increase in the number of oncological diseases among young and middle-aged people under 50 since the 1990s3
The reasons for the deteriorating public health are inadequate and unbalanced diets, alcohol and tobacco use, lack of physical activity and obesity4,5,6,7

Comprehensive support for women and giving them opportunities for timely diagnosis of precancerous conditions are the basis for creating a healthy future

If you notice pathological changes in time, continue monitoring those or start treatment (depending on a specific case) you can prevent complications that will develop into a malignant tumor.
The formation of malignant tumors is often preceded by precancerous pathologies

Precancerous conditions – what are those?

They are often asymptomatic for the patient, they can only be diagnosed by a doctor during an examination or tests.
These include benign neoplasms or chronic prolonged inflammation, which over time can develop into a malignant tumor – unless you take action, of course.

Tissue changes that are precancerous are not yet cancers

And although they are no trouble in the early stages, that's where the danger lies: women postpone a visit to the doctor and overlook their own health in the midst of household worries. If you routinely visit a specialist and get tests done, you can notice changes in you body in time and take action to prevent any further progress of cancer.

Why do precancerous conditions occur?

Benign neoplasms – for example, dysplasia of the mammary glands or cervix – are widespread: these can manifest in 50-60% of women, depending on their age.8
These phenomena are hormone-dependent and can occur due to an endocrine system malfunction, in particular, too much or too little estrogen. Women with the history of cancers in their family are at risk as well – more frequent monitoring by specialists is essential in this case.9
more than 50% of women may have benign neoplasms8

Precancerous conditions of the female reproductive system: what are these and why do they occur?

Precancerous conditions of the mammary glands

Precancerous conditions of the cervix

Precancerous conditions of the uterine body (endometrium) and ovaries

Precancerous conditions of the mammary glands

Breast dysplasia means changes in tissues that can contribute to the development of tumor cells. These tissue changes are often driven by the fluctuations in the level of estrogens in the body and if left untreated can develop into cancer.10

The development of benign mammary dysplasia (BMD) or mastopathy, as this disease is also called, can be driven by various factors, including:

  • hormonal changes caused by endocrine disorders, age-related changes, employment in hazardous industries
  • genetic predisposition – cancers diagnozed in close family members
  • pregnancy after the age of 30, no breastfeeding, abortions or pregnancy pathologies
  • long–term effects of estrogens on the body: early menstruation – before the age of 12, and late menopause - after the age of 5511

Benign mammary dysplasia is observed in 80% of women12

up to 5 times

higher risk of breast cancer
if mastopathy is diagnozed13

in 30-40 times

higher risk of breast cancer if fibroadenomas, intraductal
papillomas and lipomas are diagnozed14

What can be done?

The early stages of breast cancer (BC) and the conditions preceding these are often asymptomatic — they can only be detected during examination, therefore it is essential to:

  • do monthly self-examination (palpation) for nodes, painful thickenings in the breast
  • undergo breast ultrasound once a year - for women with close relatives who have had cancer
  • undergo mammography of both mammary glands in two projections once every 2 years from the age of 4015
  • undergo breast ultrasound every 2 years - for women under 40 if there are no complaints and cancers in the family's medical history
  • have annual checkups with a gynecologist

A gynecologist, a mammologist, a physician, an ultrasound doctor, a radiologist, and an oncologist participate in the diagnosis of breast cancer – proper routing of the patient increases the likelihood of timely diagnosis and effective treatment

Modern medicine not only successfully copes with breast cancer in the early stages, but also helps prevent benign tumors from turning into malignant ones.

For this purpose, there are various medications for mastopathy, which can be prescribed by a specialist, as well as specialized nutrients based on bioactive molecules of indole-3-carbinol and epigallocatechin-3-gallate for the purpose of correcting the diet. Studies show that the use of indole-3-carbinol not only improves the quality of life of women with mastopathy, but also can slow down the development of oncological disorders in breast cells. Therefore, it is important to undergo regular screening to help detect the division of breast cells in time, slow it down or stop it.

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Precancerous conditions of the cervix

Cervical dysplasia (CD) is a pathological condition that is not yet cancerous, but can lead to a malignant transformation. With dysplasia, cells are already beginning to change due to chronic inflammatory processes, hormonal disorders or immune status, but this process can be stopped before it develops into a cancer.16

The main factor in the development of cervical cancer is HPV (human papillomavirus)17

The possible causes of transmission and development of infection can be:

  • traumatic injuries of the cervix, for example, during abortion18
  • cervical dysplasia
  • early onset of sexual activity
  • frequent change of sexual partners
  • sexually transmitted infections
  • smoking cigarettes and vapes that have a negative effect on the immune system
in 99,7%
of cases

cervical cancers are linked to HPV19

Low awareness of preventive measures for the pre-cancers of the cervix is a critically important issue

Women have little to no awareness about cervical cancer being a potentially preventable disease. The development of cervical cancer is associated with the presence of HPV. Timely detection of cervical dysplasia at an asymptomatic stage and timely treatment may help prevent a malignant transformation.

only 15% of women
correctly indicate that HPV is the main factor in the development of cervical cancer20

What can be done?

It is impossible to determine the conditions preceding cervical cancer on your own, therefore it is essential to:

  • annually undergo a preventive screening done by a gynecologist
  • undergo a colposcopic examination in case of detected changes – as per doctor's instructions
  • undergo annual cytological screening for abnormal cells
  • HPV vaccination, which is also one of the methods of preventing cervical cancer, can be done at the age of 9 to 45 if there is no virus detected

No symptoms or complaints are not a legitimate reason to skip a visit to a specialist.

Asymptomatic disease can be deceptive, and then valuable time is lost.

In the meantime, Russia has effective surgical methods and medications with targeted effect against precancerous conditions of the cervix with HPV infection - the above solutions help successfully target dysplasia.

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Precancerous conditions of the endometrium and ovaries

Cancers of the uterus and ovaries are among the 10 most common cancers in women.21 Unlike breast and cervical cancers, these are often accompanied by concomitant diseases that lead to malignant tumors.

up to 30% of women
are diagnosed with uterine myoma every year22
  10% of women
of the reproductive age and almost 50% of women with infertility are diagnosed with endometriosis every year23
up to 40% of women
suffer from endometrial hyperplasia24

Causes of uterine body (endometrial) cancer and ovarian cancer:25

  • myomas are benign tumors in the uterine body
  • adenomyosis is a chronic disease that is associated with the endometrial tissue growing into the muscular wall of the uterus
  • endometrial hyperplasia is a pathological overgrowth of the endometrium, which can eventually undergo a malignant transformation
  • menorrhagia is excessive blood loss during menstruation caused by the irregular secretory function of the ovaries
  • endometriosis is a chronic disease associated with the growth of the tissue of the uterine mucosa (endometrium) outside the uterus

Hormonal imbalance is the main cause of cancer of the reproductive system

Hormonal imbalance is the main cause of cancer of the reproductive system.26

Estrogens make a woman a woman. Lack or excess of these hormones affects the entire reproductive system, including the development of precancerous and atypical conditions. Some pathological changes, such as benign myomas and cysts, can be surgically removed. But without the normalization of hormonal imbalances, these treatments will not work long-term: the body will continue its "faulty" operation thus contributing to the development of repeated neoplasms.

What can be done?

The best way to prevent the risk of uterine and ovarian cancer is to systematically visit a gynecologist and undergo regular examinations.

What else is important to pay attention to: 

  • taking oral contraceptives: only after endocrine tests and only as prescribed by a gynecologist
  • weight control: it is known that obesity can be one of the risk factors for uterine cancers
  • active lifestyle

Additionally, one can support their diet by taking biologically active supplements that contain active substances of natural origin, help correct metabolic disorders and have anti-inflammatory properties

The biologically active supplement "Promisan®*" is designed specifically to support the healthy functioning of a woman's reproductive system: ovaries, uterus, endometrium, breast. Indole-3-carbinol and epigallocatechin-3-gallate in Promisan contribute to reducing the risk of mastopathy and tumors of the reproductive system. Indole-3-carbinol and epigallocatechin-3-gallate have protect hormone-sensitive tissues such as the mammary gland, uterus, cervix, endometrium and other hormone-dependent tissues. Therefore, these biologically active supplements are recommended to be used to support the healthy functioning of the female reproductive system.

*Dietary supplement, not a medication

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HORMONAL IMBALANCE IS THE CAUSE OF PRECANCEROUS CONDITIONS

Estrogens are female sex hormones defining the ability to conceive and bear a child, mental and emotional state, formation of the skeleton and secondary sexual characteristics, blood quality and density of vascular walls, skin health and general mood.
The main reason for the development of precancerous conditions is an imbalance between two types of hormones: estrogen and progesterone26

What could be the reason for the estrogen and progesterone imbalances?

Only lab tests can accurately determine the levels of various hormones in the body, however, there are symptoms that can signal failures:

Do not miss the symptoms of hormonal disorders:

an excess of estrogen can cause endometriosis, myomas, mastopathy and other conditions. Early relief of conditions associated with abnormal estrogen levels can prevent deterioration.

After noticing these changes, contact a specialist and undergo necessary examinations. After determining the hormone levels, your doctor can decide on a treatment.

Prevention and detection of conditions associated with hormonal imbalance (estrogen and progesterone)

Correction of hormonal disorders is possible as indicated by a medical specialist

Specific treatment can only be prescribed by a doctor based on the results of an examination and tests performed, but the following general recommendations can be useful to all women:

Additionally, one can support their diet by taking biologically active supplements that contain active substances of natural origin to help correct metabolic disorders

Biologically active food supplement 'TIME FACTOR®'* is designed for young and middle-aged women. It contains standardized plant extracts of ginger root, angelica root, chaste tree berries, as well as glutamic acid, tocopherol acetate, rutin, electrolytic iron, folic acid, ascorbic acid, magnesium oxide, indole-3-carbinol, zinc citrate.

The biologically active supplement 'TIME FACTOR®'* is aimed at normalizing the menstrual cycle, regulating its duration, maintaining hormonal balance and mitigating premenstrual symptoms. The components are divided between the two capsules, which contain necessary plant extracts and biologically active molecules.

Formula of 'TIME FACTOR®'* is created taking into account cyclical changes in a woman's body and supports the needs of the female body throughout the menstrual cycle to the fullest extent.

*Dietary supplement, not a medication

The balance of sex hormones is a prerequisite for normal functioning of all organs and systems of the female body

Pathologies develop due to both a lack and excess of estrogens. External signs can signal changes in the body, but only a regular medical examination – at least once a year – will help get the full picture, diagnose precancerous conditions in time and prevent the development of malignant neoplasms.
medical exam at least once a year

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